I was recently told at work that there are an endless number of genders. That is because gender is a human construct, so each person can invent a gender for themselves many times throughout their lives. They might grant that there are two sexes, male and female, but according to this view, gender is not the same as sex. Gender is about how to live out your life.
Just because something is a human construct does not mean it is mistaken or false. Humans might have constructed something because they understood the nature of reality.
But I think there is a more serious problem here. Even if we grant that sex and gender are different and that gender is about how to live out your life, we are still left with this truth: God created sex (male and female) and also provided a moral law about how each is to live (which means the moral law instructs us about gender as well).
We know from general revelation that these two things are true (God created male/female, and there is a moral law). We are also told this very early in scripture (Genesis 1:26-27). The more serious thing going on here is that questioning gender is really asking: Did God really say . . . ? It is the same as the first temptation. It is questioning the Word of God and revealing when the tempted has failed to understand the Word.
There are only a few options:
There is no God and therefore there is no Word of God.
God is real, but God has nothing to say about gender.
God is real, but God does not say that there are two genders.
Each of these tempts by asking if God really did say what Genesis 1:26-27 reports. From there, they might even go so far as to say that there is no God at all or that God is absent and not involved in human life. Or perhaps, as in #3, they teach another god (such as Aphrodite) who just wants humans to have sex in whatever way they want.
This cultural debate serves the same purpose as the original temptation. It reveals if we know or we only think we know. Do you know the Word of God?